Ye et al utilize multi-omics analysis to determine the wider impacts of high-CO2 and warming temperatures on metabolite transfer between primary and secondary producers. Current evidence suggests that under future global change conditions, biochemical changes in primary producers may be transferred to higher trophic levels, potentially disrupting physiological performance and altering marine food-webs. Multi-omics analysis on metabolite transfer between marine cultured diatom (primary producer) Phaeodactylum tricornutum and the clam (secondary producer) Coelomactra antiquata showed that changes in biochemical and metabolome pathways in the primary producer, were transferred to the secondary producer. It provides evidence that the effects of future global change occur even on the molecular level, and that the inclusion of -omics data in marine-ecosystem models may be necessary in improving the accuracy of future modelling predictions.